The effect of binder concentration in fluidized-bed granulation: Transition between wet and melt granulation
نویسندگان
چکیده
منابع مشابه
Influence of binder droplet dimension on granulation rate during fluidized bed granulation.
Here, we statistically identified the critical factor of the granulation rate during the fluidized bed granulation process. Lactose was selected as the excipient and was granulated with several binders, including hydroxypropyl cellulose, hydroxypropyl methyl cellulose, and polyvinylpyrrolidone. The viscosity, density, and surface tension of the binder solution, contact angle, and the work done ...
متن کاملGranulation Time in Fluidized Bed Granulators
Size enlargement of fine powders by wet granulation involves mixing of fine particles with a binder liquid to form larger wet granules and drying them by evaporation of the binder liquid to form larger dry granules. Identification of the time for completion of granulation process is critical as further mixing of dry granules is providing extra energy for their attrition. In a batch fluidized be...
متن کاملThe Effect of Sulfate Concentration on COD Removal and Sludge Granulation in UASB Reactors
Four identical 37.5 Liter UASB reactors R1, R2, R3 and R4 were used to study the effect of sulfate concentration on granule formation. Diluted molasses with COD range 1000–1300 mg/l were used as feed and acclimated cow manure was used as seed. Concentration of sulfate ions in the four reactors were 100, 500, 1000 and 1500mg/l. Granules were observed in R2 after 33 days from startup time, while ...
متن کاملWet Granulation Process via Foams and Drops
Wet granulation using foaming binder solution is a new approach of liquid delivery to create granules. This study compares wet granulation via foamed binder addition method and sprayed binder addition method by studying the kinetics of foam and drop penetrations into loosely packed powder beds. Foam and drop nucleation kinetics were compared by examining specific penetration time (penetration t...
متن کاملEvaluation of the effect of granulation processing parameters on the granule properties: Lactose- Cornstarch case study
Understanding the relationship between processing parameters of fluidized bed wet granulation and the characteristics of intermediate and final products is crucial in the pharmaceutical processes. This research examined a fluidized bed wet granulation process containing a cornstarch solution as binder and lactose particles as powder. The design of experiment (DoE) was performed according to an ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemical Engineering Research and Design
سال: 2018
ISSN: 0263-8762
DOI: 10.1016/j.cherd.2017.11.046